After more than a year of absence, the 10th edition aims at bringing together the junior and senior scientists tip toeing on the tight rope between biology, physics, engineering and chemistry. Indeed, understanding the building blocks of life, from viruses and bacteria to tissues and organs, requires a highly multidisciplinary community that the Nanosciences Foundation has made its motto to federate.
8h45 : Accueil
5 long talks
12h : Flash posters presentation
14h30 : Conference of Nicolas Biais
5 short talks
17h25 : Posters prizes award
This talk will introduce the most ubiquitous of bacterial appendages : the Type IV pilus. Type IV pili (Tfp) are thin (6 to 9 nm in diameter) and long (up to several microns) biological polymers that can achieve cycles of elongation and retraction away from bacterial bodies. These incredible nanomachines mediate many bacterial functions from DNA uptake to motility, infection and more. For most of those functions, the ability of Tfp to exerce physical forces ranging from a few pN to a few nN is critical. We will present biophysical characterizations of these nanomachines across evolutionary timescales and explore the role of the mechanical forces that bacteria can achieve using Tfp on bacteria-host and bacteria-bacteria interactions. Similarly to our recent recognition of the role of mechanical forces in the biology of multicellular mammalian cells we will show that mechanics also contribute to the biology of bacteria.